901566

Propargyl-PEG₂-acid

• 実験式（ヒル表記法）: C₈H₁₂O₄
• CAS番号: 1859379-85-3
• 分子量: 172.18
• MDL番号: MFCD29764323
• UNSPSCコード: 12352106
• NACRES: NA.22

特性

• フォーム: liquid
• 反応適合性: reaction type: click chemistry; reagent type: linker
• 官能基: alkyne; carboxylic acid
• 保管温度: −20°C
• SMILES記法: C#CCOCCOCCC(O)=O
• InChI: 1S/C8H12O4/c1-2-4-11-6-7-12-5-3-8(9)10/h1H,3-7H2,(H,9,10)
• InChI Key: NNWHATPXNWOQKD-UHFFFAOYSA-N

詳細

アプリケーション

Propargyl-PEG₂-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG₂-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains two PEG units to help improve solubility.

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3