250233

Cytochalasin B

from Helminthosporium dematioideum, ≥98% (HPLC), solid, cell-permeable fungal toxin, Calbiochem^®

• 別名: Cytochalasin B, Helminthosporium dematioideum
• 実験式（ヒル表記法）: C₂₉H₃₇NO₅
• CAS番号: 14930-96-2
• 分子量: 479.61
• MDL番号: MFCD00077704
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: Cytochalasin B, Helminthosporium dematioideum, Cell-permeable fungal toxin.
• 品質水準: 100
• 詳細: Merck USA index - 14, 2790
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: methanol: 20 mg/mL; DMSO: 50 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: N1[C@H]([C@H]3[C@@]4(OC(=O)\C=C\[C@@H](CCC[C@H](C\C=C\[C@H]4[C@@H](C(=C)[C@H]3C)O)C)O)C1=O)Cc2ccccc2
• InChI: 1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
• InChI Key: GBOGMAARMMDZGR-TYHYBEHESA-N

詳細

詳細

Cell-permeable fungal toxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Shortens actin filaments by blocking monomer addition at the fast growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Blocking the formation of contractile microfilaments

Product does not compete with ATP.

Reversible: no

注意

Poor quality DMSO will cause degradation of the product, so high quality DMSO is recommended.

警告

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

再構成

Following reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Tanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.
Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
Cairns, M.T., et al. 1991. J. Biol. Chem.266, 8176.
Nowak, D. 1990. Biomed. Biochim. Acta49, 353.
Wang, F., et al. 1990. Biochem. Biophys. Res. Commun.171, 543.
Edwards, S.W., and Lloyd, D. 1988. FEBS Lett.227, 39.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H300 + H310 + H330,H361
• 注意書き: P201 - P202 - P260 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• 危険有害性の分類: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Repr. 2
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3