3541

Glutathione, Reduced, Free Acid

>98% (titration), solid, endogenous antioxidant, Calbiochem^®

• 別名: Glutathione, Reduced, Free Acid, γ-Glu-Cys-Gly, GSH
• 実験式（ヒル表記法）: C₁₀H₁₇N₃O₆S
• CAS番号: 70-18-8
• 分子量: 307.32
• MDL番号: MFCD00065939
• UNSPSCコード: 12352209
• NACRES: NA.25

特性

• 製品名: Glutathione, Reduced, Free Acid, Glutathione, Reduced, Free Acid, CAS 70-18-8, is a tripeptide that serves as an endogenous antioxidant and provides protection against auto-oxidation.
• 品質水準: 200
• アッセイ: >98% (titration)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: water: 1 mg/mL; DMF: 10 mg/mL; ethanol: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: SCC(NC(=O)CCC([N+H3])C(=O)[O-])C(=O)NCC(=O)O
• InChI: 1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)
• InChI Key: RWSXRVCMGQZWBV-UHFFFAOYSA-N

詳細

詳細

Glutathione is a tripeptide composed of cysteine, glycine, and glutamic acid. In cells glutathione either exists as reduced (GSH) and oxidized (GSSG). The ratio of glutathione reduced (GSH) to glutathione oxidized (GSSG) determines the cell’s redox status. Healthy resting cells have a GSH/GSSG ratio >100. In cells under oxidative stress, the GSH/GSSG ratio drops to between 1 and 10. Glutathione has also been identified as the thiol buffer that keeps sulfohydryl groups in the reduced form of many proteins. It is produced solely in the cytochrome P450 system and actively pumped to mitochondria. GSH depletion can lead to Neurodegenerative disorders, Pulmonary disease, Immune diseases, Cardiovascular diseases, Chronic age-related diseases, Liver disease, Cystic fibrosis and Aging process itself.

アプリケーション

Glutathione, Reduced, Free Acid has been used to elute the GST-OTUD6A proteins after purification using Glutathione Sepharose.

生物化学的／生理学的作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable