A8326

抗β-アミロイドタンパク質 (1-40) ウサギ宿主抗体

whole antiserum

• 別名: Anti-AAA, Anti-ABETA, Anti-ABPP, Anti-AD1, Anti-APPI, Anti-CTFgamma, Anti-CVAP, Anti-PN-II, Anti-PN2, Anti-alpha-sAPP, Anti-preA4
• MDL番号: MFCD00212892
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: whole antiserum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: liquid
• 含みます: 15 mM sodium azide
• 化学種の反応性: human
• 強化検証: independent; Learn more about Antibody Enhanced Validation
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using human Alzheimer’s disease (AD) brain tissue; indirect ELISA: 1:4000-1:8000
• UniProtアクセッション番号: P05067
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... APP(351)

詳細

詳細

Amyloid precursor proteins (APPs) are members of a large family of 70 kDa transmembrane glycoproteins that are found in a wide range of tissues. APP is expressed in the brain. It is located on human chromosome 21. APPs have three main isoforms, namely, APP₆₉₅, APP₇₅₁ and APP₇₇₀, that are derived from alternative splicing events in cells.

免疫原

合成β-アミロイド(1-40)のBSA結合体。

アプリケーション

Anti-β-Amyloid Protein (1-40) antibody produced in rabbit has been used in:

• immunocytochemical localization of Aβ peptides
• immunocytochemistry
• immunoprecipitation
• focused ultrasound-microbubble enhanced antibody delivery (FUS-MB)

生物化学的／生理学的作用

The β-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes β-secretase (BACE1) and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42 and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of Aβ leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer′s disease (AD).
Rabbit Anti-β-Amyloid Protein (1-40) antibody does not stain control sections of normal brain tissues.

物理的形状

Rabbit Anti-β-Amyloid (1-40) is supplied as a liquid containing 0.1% sodium azide as preservative.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable