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product name
Fibronectin-FITC, FITC-labeled human plasma fibronectin, Suitable for cell culture
品質水準
形状
liquid
保管条件
protect from light
輸送温度
dry ice
保管温度
−20°C
詳細
Fibronectin is purified from human plasma (Cat. No. F0895). The protein is modified to contain covalently linked Fluorescein 5-isothiocyanate (Cat. No. F7250).
Fibronectin, also known as Cold-insoluble globulin, is a large glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. Fibronectin is a ubiquitous and essential component of the extracellular matrix (ECM) and plays a vital role during tissue repair. Fibronectin functions both as a regulator of cellular processes and an important scaffolding protein to maintain and direct tissue organization and ECM composition. Fibronectin plays an important role in cell adhesion and spreading and affect the routes of cell migration both in vivo and in culture.
Proteolytic degradation of extracellular matrix (ECM) is a critical step during cell invasion and tissue transmigration that is required for many physiological and pathological processes. Cellular structures that mediate cell adhesion to, degradation of, and invasion into ECM are invadopodia of transformed and tumor cells and podosomes of osteoclasts, macrophages, normal monocytic, endothelial, and smooth muscle cells. The ability to degrade extracellular matrix (ECM) is a hallmark of invasive tumors and is thought to be essential for the movement of cancer cells through tissue barriers.
The invadopodia assay is method that has been most informative for pinpointing regions of the cell that initiate invasion involve plating cells on a culture surface coated with a thin layer of fluorescently labeled matrix, and visualizing regions where the cell has degraded the matrix to create an area devoid of fluorescence.The assay have revealed that invasive cells extend small localized protrusions that degrade the matrix. This invadopodia invasion assay may be used for assessing activity of different cell types as well as individual cells in heterogeneous populations may be analyzed for invasive potential. The number and invadopodia activity are sensitive to some physical or chemical factors such as: cell type, matrix rigidity, density of cell layer.
Fibronectin, also known as Cold-insoluble globulin, is a large glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. Fibronectin is a ubiquitous and essential component of the extracellular matrix (ECM) and plays a vital role during tissue repair. Fibronectin functions both as a regulator of cellular processes and an important scaffolding protein to maintain and direct tissue organization and ECM composition. Fibronectin plays an important role in cell adhesion and spreading and affect the routes of cell migration both in vivo and in culture.
Proteolytic degradation of extracellular matrix (ECM) is a critical step during cell invasion and tissue transmigration that is required for many physiological and pathological processes. Cellular structures that mediate cell adhesion to, degradation of, and invasion into ECM are invadopodia of transformed and tumor cells and podosomes of osteoclasts, macrophages, normal monocytic, endothelial, and smooth muscle cells. The ability to degrade extracellular matrix (ECM) is a hallmark of invasive tumors and is thought to be essential for the movement of cancer cells through tissue barriers.
The invadopodia assay is method that has been most informative for pinpointing regions of the cell that initiate invasion involve plating cells on a culture surface coated with a thin layer of fluorescently labeled matrix, and visualizing regions where the cell has degraded the matrix to create an area devoid of fluorescence.The assay have revealed that invasive cells extend small localized protrusions that degrade the matrix. This invadopodia invasion assay may be used for assessing activity of different cell types as well as individual cells in heterogeneous populations may be analyzed for invasive potential. The number and invadopodia activity are sensitive to some physical or chemical factors such as: cell type, matrix rigidity, density of cell layer.
保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
F2733-1ML:
F2733-VAR:
F2733-BULK:
試験成績書（COA）
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