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Merck

G0299

Sigma-Aldrich

Protodioscin

from Dioscorea spp., ≥98% (HPLC)

別名:

Furostanol I

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About This Item

実験式(ヒル表記法):
C51H84O22
CAS番号:
分子量:
1049.20
UNSPSCコード:
12352212
NACRES:
NA.25

由来生物

Dioscorea spp.

品質水準

アッセイ

≥98% (HPLC)

形状

powder

アプリケーション

metabolomics
vitamins, nutraceuticals, and natural products

保管温度

2-8°C

InChI

1S/C51H84O22/c1-20(19-65-45-39(60)38(59)35(56)30(17-52)69-45)9-14-51(64)21(2)32-29(73-51)16-28-26-8-7-24-15-25(10-12-49(24,5)27(26)11-13-50(28,32)6)68-48-44(72-47-41(62)37(58)34(55)23(4)67-47)42(63)43(31(18-53)70-48)71-46-40(61)36(57)33(54)22(3)66-46/h7,20-23,25-48,52-64H,8-19H2,1-6H3/t20-,21+,22+,23+,25+,26-,27+,28+,29+,30-,31-,32+,33+,34+,35-,36-,37-,38+,39-,40-,41-,42+,43-,44-,45-,46+,47+,48-,49+,50+,51-/m1/s1

InChI Key

LVTJOONKWUXEFR-UEZXSUPNSA-N

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詳細

Protodioscin is a steroidal saponin found in a variety of plant species. It consists of aglycone and glycone moieties and occurs as an active ingredient of the herbal aphrodisiac Tribulus terrestris used in traditional Chinese and Indian medicine.

アプリケーション

Protodioscin has been used to study the inhibitory effect of fenugreek and quinoa extracts on the activity of α-amylase and pancreatic lipase under in vitro traditional conditions. It has also been used as a standard in the study to carry out the structural characterization of the steroidal saponins extracted from Smilax trinervula.

生物化学的/生理学的作用

Protodioscin shows a notable inhibitory effect on digestive enzymes such as α-amylase and pancreatic lipase. It is posited to increase the levels of testosterone, luteinizing hormone, dehydroepiandrosterone, dihydrotestosterone, and dehydroepiandrosterone sulfate along with improving libido and spermatogenesis in humans and animals. It exhibits anti-tumor activity especially against leukemia, colon cancer, and prostate cancer.
Saponin phytochemical found in asparagus. Cardioprotective and anti-hyperlipidemic agent. Cytotoxic effect against human cancer cell lines.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

G0299-VAR:
G0299-50MG:
G0299-BULK:
G0299-10MG:


試験成績書(COA)

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Kalamegam Gauthaman et al.
Journal of alternative and complementary medicine (New York, N.Y.), 9(2), 257-265 (2003-06-14)
Apart from its claims for improvement of sexual functions in men, the puncturevine plant (Tribulus terrestris: TT) has long been considered as an energizer and vitalizer in the indigenous system of medicine. Sexual behavior and intracavernous pressure (ICP) measurements were
K Gauthaman et al.
Life sciences, 71(12), 1385-1396 (2002-07-20)
Tribulus terrestris (TT) has long been used in the traditional Chinese and Indian systems of medicine for the treatment of various ailments and is popularly claimed to improve sexual functions in man. Sexual behaviour and intracavernous pressure (ICP) were studied
Ke Hu et al.
Planta medica, 68(4), 297-301 (2002-05-04)
Protodioscin (NSC-698 796) is a furostanol saponin isolated from the rhizome of Dioscorea collettii var. hypoglauca (Dioscoreaceae), a Chinese herbal remedy for the treatment of cervical carcinoma, carcinoma of urinary bladder and renal tumor for centuries. To systematically evaluate its
Teresa Herrera et al.
Food chemistry, 270, 509-517 (2018-09-04)
Ethanol extracts (EE) from fenugreek and quinoa seeds with different total content of inhibitory compounds (TIC, total saponin plus phenolic) were prepared with and without concentration of TIC (CEE -concentrated EE-, and EE, respectively). Their inhibitory activity on pancreatic lipase
Yonghong Liang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 974, 75-82 (2014-12-03)
Steroid saponins are a class of naturally existing substances widely distributed in the plants of Smilacaceae. Their biological activities have been attracting the interest of scientists in the chemical field for the past few years. To our best knowledge, there

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