G9518

ゲムフィブロジル

• 別名: 2,2-ジメチル-5-(2,5-ジメチルフェノキシ)ペンタン酸
• 実験式（ヒル表記法）: C₁₅H₂₂O₃
• CAS番号: 25812-30-0
• 分子量: 250.33
• EC Number: 247-280-2
• MDL番号: MFCD00079335
• UNSPSCコード: 12352200
• PubChem Substance ID: 24895377
• NACRES: NA.77

特性

• フォーム: powder
• 品質水準: 100
• SMILES記法: Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1
• InChI: 1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
• InChI Key: HEMJJKBWTPKOJG-UHFFFAOYSA-N
• 遺伝子情報: human ... PPARA(5465)

詳細

詳細

Gemfibrozil is a fibric acid derivative and a hypolipidemic drug. Gemfibrozil serves as a ligand for PPARα (peroxisome proliferator-activated receptor α).

アプリケーション

Gemfibrozil has been used to to study its effects on cell cycle progression in yeast. It has been used to study the effects of fibrates on cell proliferation and gene expression in human cell lines.

生物化学的／生理学的作用

Gemfibrozil selectively increases Apolipoprotein A-I levels. In yeast cells, application of gemfibrozil delays the start of DNA replication. It is used as a therapeutic agent for dyslipidemia.

特徴および利点

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 + P330 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves