S8139

スリンダク

≥98.0%

• 別名: (Z)-5-フルオロ-2-メチル-1-[p-(メチルスルフィニル)ベンジリデン]インデン-3-酢酸
• 実験式（ヒル表記法）: C₂₀H₁₇FO₃S
• CAS番号: 38194-50-2
• 分子量: 356.41
• EC Number: 253-819-2
• MDL番号: MFCD00599589
• UNSPSCコード: 12161501
• PubChem Substance ID: 57654635
• NACRES: NA.77

特性

• 由来生物: synthetic (organic)
• 品質水準: 200
• アッセイ: ≥98.0%
• 形状: powder
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• 溶解性: methanol: 50 mg/mL
• アプリケーション: forensics and toxicology; veterinary
• オーガナイザー: Merck & Co., Inc., Kenilworth, NJ, U.S.
• SMILES記法: CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(C)=O
• InChI: 1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
• InChI Key: MLKXDPUZXIRXEP-MFOYZWKCSA-N
• 遺伝子情報: human ... ALB(213) , PTGS1(5742) , PTGS2(5743)

詳細

アプリケーション

Treatment of human colorectal cancer cell lines induces MRP1 and MRP3 but not other members of the MRP family. Reported to significantly increase the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine. Sulindac was tested for its effect on heat-induced denaturation of albumin in vitro²⁸ and its ability to bind to human plasma protein.²⁹

生物化学的／生理学的作用

Sulindac is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells^25,26 and reduces tumor burden in adenomatous polyposis patients.²⁷

非ステロイド系抗炎症薬であり、COX-1の選択的インヒビタ-です。

特徴および利点

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301,H317,H334,H361
• 注意書き: P201 - P280 - P301 + P310 + P330 - P302 + P352
• 危険有害性の分類: Acute Tox. 3 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges