SML1497

Canrenone

≥97% (HPLC)

• 別名: (17α)-17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone, NSC 261713
• 実験式（ヒル表記法）: C₂₂H₂₈O₃
• CAS番号: 976-71-6
• 分子量: 340.46
• MDL番号: MFCD00071735
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825921
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: powder
• 光学活性: [α]/D +17 to +24°, c = 1 in chloroform-d
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: room temp
• SMILES記法: C[C@@]12C(C=C[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]45OC(CC5)=O)=CC(CC1)=O
• InChI: 1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h3-4,13,16-18H,5-12H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
• InChI Key: UJVLDDZCTMKXJK-WNHSNXHDSA-N
• 遺伝子情報: human ... NR3C2(4306)

詳細

生物化学的／生理学的作用

Canrenone is a mineralocorticoid (aldosterone) inhibitor.

Canrenone is a mineralocorticoid (aldosterone) inhibitor. Aldosterone is known to be involved in hypertension, kidney disease, atherosclerosis, and heart failure. Blockade of the aldosterone receptor has been shown to improve cardiovascular function. In congestive heart failure, aldosterone antagonists are used in addition to other drugs for additive diuretic effect, which reduces edema and the cardiac workload.
Canrenone is an active metabolite of spironolactone with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor in the kidneys, thereby increasing sodium excretion and inhibiting potassium excretion. It is known to reduce the inflammatory reaction influenced by aldosterone.

安全性情報

• ピクトグラム: GHS08,GHS09
• シグナルワード: Warning
• 危険有害性情報: H351,H411
• 注意書き: P202 - P273 - P280 - P308 + P313 - P391 - P405
• 危険有害性の分類: Aquatic Chronic 2 - Carc. 2 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable