SML2283

Lenalidomide

≥98% (HPLC), powder, cereblon binder

• 別名: Lenalidomide, 1-Oxo-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole, 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione, 3-(4-Amino-1-oxoisoindolin-2-yl)piperidin-2,6-dione, 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, CC 5013, CC-5013
• 実験式（ヒル表記法）: C₁₃H₁₃N₃O₃
• CAS番号: 191732-72-6
• 分子量: 259.26
• MDL番号: MFCD07772307
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 製品名: Lenalidomide, ≥98% (HPLC)
• ligand: lenalidomide
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 反応適合性: reagent type: ligand
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N
• InChI: 1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
• InChI Key: GOTYRUGSSMKFNF-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Lenalidomide, a derivative of thalidomide, is an immunomodulatory agent that is approved drug for treatment of multiple myeloma. Apparently Lenalidomide is a ligand of ubiquitin E3 ligase cereblon that induces the enzyme to degrade the Ikaros transcription factors IKAROS family zinc finger 1 (IKZF1) and IKZF3. Lenalidomide possess pleiotropic antitumor effects. It is used in the treatment of 5q-deletion associated myelodysplastic syndrome (del(5q)-MDS).

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H360D,H373
• 注意書き: P202 - P260 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Repr. 1B - STOT RE 2
• ターゲットの組織: Blood
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable