T6137

トリオキシサレン

≥98% (HPLC), powder, photochemical DNA crosslinker

• 別名: 2,5,9-トリメチルフロ[3,2-g]ベンゾピラン-7-オン, 4,5′,8-トリメチルソラレン, TMP, トリソラレン
• 実験式（ヒル表記法）: C₁₄H₁₂O₃
• CAS番号: 3902-71-4
• 分子量: 228.24
• Beilstein: 221723
• EC Number: 223-459-0
• MDL番号: MFCD00005010
• UNSPSCコード: 12352200
• PubChem Substance ID: 24900351
• NACRES: NA.77

特性

• product name: トリオキシサレン, ≥98% (HPLC), powder
• 品質水準: 200
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white
• mp: 229-231 °C (lit.)
• 溶解性: chloroform: soluble 50 mg/mL, clear, colorless to faintly yellow
• 蛍光検出: λ_ex 269 nm; λ_em 445 nm in methanol; λ_ex 321 nm; λ_em 445 nm (bound to DNA in Tris, pH 8.1)
• オーガナイザー: Valeant
• 保管温度: −20°C
• SMILES記法: Cc1cc2cc3C(C)=CC(=O)Oc3c(C)c2o1
• InChI: 1S/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3
• InChI Key: FMHHVULEAZTJMA-UHFFFAOYSA-N

詳細

アプリケーション

Trioxsalen has been used for mutagenesis of N2 worms^4,5.

Trioxsalen has been used:

• to induce small deletion mutations in worms
• in combination with ultraviolet A (UVA)
• to induce interstrand crosslinks (ICLs) in DNA
• for the preparation and photoactivation of trimethyl psoralen

生物化学的／生理学的作用

核酸の構造・機能研究のプロ-ブとして使用されるDNAの光架橋剤です。トリオキシサレンは、雲母表面でのDNAの架橋にも用いられています。

Trioxsalen (TRX) is a 4,5′,8-trimethylated psoralen analog, which belongs to the family of furocoumarins. It is mostly used to treat psoriasis.

特徴および利点

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Valeant. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

調製ノート

Trioxsalen is soluble in chloroform at 50 mg/ml and yields a clear, colorless to faint yellow solution.

安全性情報

• ピクトグラム: GHS08,GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H312 + H332,H314,H341
• 注意書き: P202 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Dam. 1 - Muta. 2 - Skin Corr. 1B
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges