T8951

Tangeretin

≥95% (HPLC)

• 別名: 4′,5,6,7,8-Pentamethoxyflavone, 5,6,7,8-Tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one, NSC 53909, NSC 618905, Ponkanetin
• 実験式（ヒル表記法）: C₂₀H₂₀O₇
• CAS番号: 481-53-8
• 分子量: 372.37
• Beilstein: 351695
• EC Number: 207-570-1
• MDL番号: MFCD00017438
• UNSPSCコード: 12352205
• PubChem Substance ID: 329826890
• NACRES: NA.25

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• アプリケーション: metabolomics; vitamins, nutraceuticals, and natural products
• SMILES記法: COc1ccc(cc1)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
• InChI: 1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3
• InChI Key: ULSUXBXHSYSGDT-UHFFFAOYSA-N

詳細

詳細

Tangeretin is a polymethoxyflavone extracted primarily from the peels of citrus fruits like Citrus sinensis and Citrus reticulata.

アプリケーション

Tangeretin has been used as an antioxidant and antifungal agent to test its effects on ferroptosis inhibition, conidial development, and appressorium formation against Magnaporthe oryzae. It has also been used as a co-chemotherapeutics agent to study its cytotoxic effects in combination with 5-Fluorouracil (5-Fu) on WiDr colon cancer cells.

生物化学的／生理学的作用

Tangeretin displays its anti-cancer effects by modulating different pathways in several cancer types in both in-vitro and in-vivo studies. It also exerts antioxidant, anti-inflammatory, and estrogenic properties.

Tangeretin is a flavonoid found in the peel of citrus fruits where it most likely provides natural resistance to fungi. Tangeretin has been shown to counteract tumor promoter-induced inhibition of intercellular communication and to inhibit cell proliferation in several cancer lines.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges