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Merck
모든 사진(1)

주요 문서

47618

Sigma-Aldrich

Fmoc-Asp(OtBu)-OH

≥98.0% (HPLC), for peptide synthesis

동의어(들):

Fmoc-L-aspartic acid 4-tert-butyl ester

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About This Item

실험식(Hill 표기법):
C23H25NO6
CAS Number:
Molecular Weight:
411.45
Beilstein:
3635671
EC Number:
MDL number:
UNSPSC 코드:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

product name

Fmoc-Asp(OtBu)-OH, ≥98.0% (HPLC)

Quality Level

분석

≥98.0% (HPLC)

형태

powder

광학 활성

[α]20/D −24±2°, c = 1% in DMF

반응 적합성

reaction type: Fmoc solid-phase peptide synthesis

mp

148-150 °C (dec.)

응용 분야

peptide synthesis

작용기

Fmoc

저장 온도

2-8°C

SMILES string

CC(C)(C)OC(=O)C[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

InChI

1S/C23H25NO6/c1-23(2,3)30-20(25)12-19(21(26)27)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,26,27)/t19-/m0/s1

InChI key

FODJWPHPWBKDON-IBGZPJMESA-N

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일반 설명

Fmoc-Asp(OtBu)-OH also known as Fmoc-L-aspartic acid 4-tert-butyl ester, is a Fmoc protected amino acid, used in solid phase peptide synthesis.

애플리케이션

Fmoc-Asp(OtBu)-OH is used to prevent the formation of aspartimide by-products in Fmoc solid phase peptide synthesis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

New t-butyl based aspartate protecting groups preventing aspartimide formation in Fmoc SPPS
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Journal of Peptide Science, 21, 680-687 (2015)
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International journal of molecular sciences, 20(7) (2019-04-11)
The growing integration of quality-by-design (QbD) concepts in biomanufacturing calls for a detailed and quantitative knowledge of the profile of impurities and their impact on the product safety and efficacy. Particularly valuable is the determination of the residual level of
R Ashton Lavoie et al.
Biotechnology and bioengineering, 117(2), 438-452 (2019-10-28)
The clearance of host cell proteins (HCPs) is of crucial importance in biomanufacturing, given their diversity in composition, structure, abundance, and occasional structural homology with the product. The current approach to HCP clearance in the manufacturing of monoclonal antibodies (mAbs)

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