추천 제품
product name
Bone Morphogenetic Protein 2 human, BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture
생물학적 소스
human
Quality Level
재조합
expressed in HEK 293 cells
형태
lyophilized powder
효능
≤60 ng/mL EC50
품질
endotoxin tested
분자량
dimer 30-38 kDa (glycosylated)
포장
pkg of 10 μg
저장 조건
avoid repeated freeze/thaw cycles
기술
cell culture | mammalian: suitable
불순물
≤1 EU/μg Endotoxin level
UniProt 수납 번호
저장 온도
−20°C
유전자 정보
human ... BMP2(650)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Bone Morphogenetic Protein 2 is a member of the TGF-β superfamily of cytokines that affect bone and cartilage formation. It is important for skeletal development during embryogenesis. BMP-2 induces chondrocyte formation, osteoblast differentiation, and is involved in embryo dorsal-ventral patterning and organogenesis.
생화학적/생리학적 작용
It has been reported that Bone Morphogenetic Protein 2 (BMP-2) inhibits estradiol induced proliferation of human breast cancer cells. BMP-2 signaling mediates apoptosis by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors, which play significant roles in BMP binding and signaling. One BMP type II receptor and two BMP type I receptors have been identified. Both BMP type I receptors bind BMP-2 with high-affinity in the absence of BMP receptor type II.
물리적 형태
Lyophilized from a 0.2 μm filtered solution of 2x PBS + 6% Ethanol.
제조 메모
This Bone Morphogenetic Protein 2 (BMP-2) is produced from a DNA sequence encoding the human BMP-2 protein, expressed in HEK 293 cells. It is a glycosylated homodimer linked by a single disulfide bond with an apparent molecular mass of 30-38 kDa.
분석 메모
The specific activity was determined by its ability to induce alkaline phosphatase production in a dose response to BMP-2 in the ATDC-5 cell line (mouse chondrogenic cell line).
법적 정보
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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문서
Hydrogel-based biomaterials for cell delivery and tissue regeneration applications are discussed.
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