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Sigma-Aldrich

Fluorescein isothiocyanate–dextran

average mol wt 2,000,000

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Synonym(s):
FITC–Dextran 2000, FITC–Dextran
CAS Number:
MDL number:
NACRES:
NA.32

biological source

synthetic

conjugate

FITC conjugate

form

powder or crystals

mol wt

average mol wt 2,000,000

extent of labeling

0.001-0.020 mol FITC per mol glucose (substitution)

fluorescence

λex 493 nm; λem 520 nm in 0.1 M Tris pH 8.0

application(s)

cell analysis

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This Item
FD10SFD2000S69658
Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

form

powder or crystals

form

powder

form

powder

form

powder or crystals

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate

mol wt

average mol wt 2,000,000

mol wt

average mol wt 10,000

mol wt

average mol wt 2,000,000

mol wt

average mol wt 150,000

extent of labeling

0.001-0.020 mol FITC per mol glucose (substitution)

extent of labeling

0.003-0.020 mol FITC per mol glucose

extent of labeling

0.003-0.020 mol FITC per mol glucose

extent of labeling

0.001-0.020 mol/mol FITC glucose

Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Fluorescein isothiocyanate–dextran (FITC–Dextran 2000) is use as a fluorescent probe to study the permeability of structures such as intercellular junctions involved in processes such as hearing and vascular permeability and the integrity of the blood brain barrier (BBB).

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Elodie Debefve et al.
Lasers in surgery and medicine, 43(7), 696-704 (2011-11-08)
Photodynamic therapy (PDT) affects vascular barrier function and thus increases vessel permeability. This phenomenon may be exploited to facilitate targeted drug delivery and may lead to a new clinical application of photodynamic therapy. Here, we investigate the role of leukocyte
Sangmi Ock et al.
Biochemical and biophysical research communications, 516(2), 350-356 (2019-06-19)
Receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily. RANKL increases endothelial permeability and induces angiogenesis, suggesting its critical roles in the vasculature. Despite the evidence implicating RANKL in vascular pathology, its role in ischemic retinopathy
Sung Ji Ahn et al.
Biomedical optics express, 11(5), 2665-2678 (2020-06-06)
We show that third harmonic generation (THG) microscopy using a 1-MHz train of 1,300-nm femtosecond duration laser pulses enabled visualization of the structure and quantification of flow speed in the cortical microvascular network of mice to a depth of >
Guiliang Zheng et al.
BMC neuroscience, 13, 71-71 (2012-06-21)
Exposure to intense noise causes the excessive movement of the organ of Corti, stretching the organ and compromising sensory cell functions. We recently revealed changes in the transcriptional expression of multiple adhesion-related genes during the acute phases of cochlear damage
Albert Y Jin et al.
BMC neuroscience, 11, 12-12 (2010-02-04)
The link between early blood- brain barrier (BBB) breakdown and endothelial cell activation in acute stroke remain poorly defined. We hypothesized that P-selectin, a mediator of the early phase of leukocyte recruitment in acute ischemia is also a major contributor

Articles

Additional information about FITC-labelled polysaccarides including FITC-Dextran, FITC-DEAE-dextran (FDD), FITC-carboxymethyl-dextran (FCM-Dextran). This page discusses the impact of weight-average molecular weight on the respective molecule dimensions and other physical properties

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