Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

M212

Sigma-Aldrich

Mastoparan-7

≥97% (HPLC), lyophilized powder

Synonym(s):

Mas 7

Sign Into View Organizational & Contract Pricing

Select a Size

100 μG
$691.00

$691.00


Estimated to ship onMarch 23, 2025


Request a Bulk Order

Select a Size

Change View
100 μG
$691.00

About This Item

Empirical Formula (Hill Notation):
C67H124N18O15
CAS Number:
Molecular Weight:
1421.81
MDL number:
UNSPSC Code:
41106300
PubChem Substance ID:
NACRES:
NA.77

$691.00


Estimated to ship onMarch 23, 2025


Request a Bulk Order

Quality Level

assay

≥97% (HPLC)

form

lyophilized powder

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

InChI

1S/C67H124N18O15/c1-18-38(12)53(71)67(100)85-51(32-52(70)86)66(99)84-50(31-37(10)11)64(97)79-45(24-20-22-26-69)61(94)75-42(16)58(91)82-47(28-34(4)5)62(95)76-39(13)55(88)73-40(14)57(90)81-48(29-35(6)7)63(96)77-41(15)56(89)78-44(23-19-21-25-68)60(93)74-43(17)59(92)83-49(30-36(8)9)65(98)80-46(54(72)87)27-33(2)3/h33-51,53H,18-32,68-69,71H2,1-17H3,(H2,70,86)(H2,72,87)(H,73,88)(H,74,93)(H,75,94)(H,76,95)(H,77,96)(H,78,89)(H,79,97)(H,80,98)(H,81,90)(H,82,91)(H,83,92)(H,84,99)(H,85,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,53-/m0/s1

InChI key

HOLQXBRPSSZJMZ-FGRXCANLSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SAB4200521AP1064676602
clone

5C6, monoclonal

clone

polyclonal

clone

polyclonal

clone

16C2, monoclonal

Gene Information

human ... VASP(7408)

Gene Information

human ... VASP(7408)
mouse ... Vasp(22323)
rat ... Vasp(361517)

Gene Information

-

Gene Information

-

species reactivity

human, mouse

species reactivity

mouse, human, rat

species reactivity

human

species reactivity

mouse, human

biological source

mouse

biological source

rabbit

biological source

rabbit

biological source

mouse

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

Amino Acid Sequence

Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Ala-Leu-Leu-NH2

General description

Mastoparan-7 is an analog of the mastoparan peptide. It is present in the venom of Vespula lewisii. It was originally isolated from wasp venom.[1]

Application

Mastoparan-7 has been used to study mastoparan-stimulated nucleotide binding to G proteins.[2]

Biochem/physiol Actions

Mastoparan-7 (Mas-7) stimulates the G protein subunit Gαo/i by its mode of action (to bind to the plasma membrane). It possesses antiviral activity and is associated with histamine release from mast cells. It is also involved in the induction of potent mitochondrial permeability and tumor cell cytotoxicity.[1]

Analysis Note

More potent analog of mastoparan.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


  • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    J F Klinker et al.
    The Biochemical journal, 304 ( Pt 2), 377-383 (1994-12-01)
    The wasp venom, mastoparan (MP), activates reconstituted pertussis toxin (PTX)-sensitive G-proteins in a receptor-independent manner. We studied the effects of MP and its analogue, mastoparan 7 (MP 7), on G-protein activation in HL-60 cells and a reconstituted system and on
    Damir Kopein et al.
    Molecular biology of the cell, 20(17), 3865-3877 (2009-07-03)
    G protein-coupled receptors (GPCRs) transduce their signals through trimeric G proteins, inducing guanine nucleotide exchange on their Galpha-subunits; the resulting Galpha-GTP transmits the signal further inside the cell. GoLoco domains present in many proteins play important roles in multiple trimeric
    Valerie T Ramírez et al.
    Neural plasticity, 2016, 4258171-4258171 (2016-02-18)
    Mastoparan-7 (Mas-7), an analogue of the peptide mastoparan, which is derived from wasp venom, is a direct activator of Pertussis toxin- (PTX-) sensitive G proteins. Mas-7 produces several biological effects in different cell types; however, little is known about how
    D P McEwen et al.
    Analytical biochemistry, 291(1), 109-117 (2001-03-23)
    Three BODIPY GTPgammaS analogs (FL, 515, and TR), BODIPY FL GppNHp and BODIPY FL GTP molecules were synthesized as possible fluorescent probes to study guanine nucleotide binding spectroscopically. Binding to G(alphao) increases baseline analog fluorescence by 6-, 8.5-, 2.8-, 3.5-
    J F Klinker et al.
    Biochemical pharmacology, 51(3), 217-223 (1996-02-09)
    The wasp venom, mastoparan (MP), is a direct activator of reconstituted pertussis toxin-sensitive G-proteins and of purified nucleoside diphosphate kinase (NDPK) [E.C. 2.6.4.6.]. In HL-60 membranes, MP activates high-affinity GTPase [E.C. 3.6.1.-] and NDPK-catalyzed GTP formation, but not photolabeling of

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service