PHR1353

エストラジオール

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: β-エストラジオール, 1,3,5-エストラトリエン-3,17β-ジオール, 17β-エストラジオール, 3,17β-ジヒドロキシ-1,3,5(10)-エストラトリエン, ジヒドロフォリクリン
• 実験式（ヒル表記法）: C₁₈H₂₄O₂
• CAS番号: 50-28-2
• 分子量: 272.38
• Beilstein: 1914275
• EC Number: 200-023-8
• MDL番号: MFCD00003693
• UNSPSCコード: 41116107
• PubChem Substance ID: 329823337
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to BP 729; traceable to Ph. Eur. E1620000; traceable to USP 1250008
• APIファミリー: estradiol
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• mp: 176-180 °C (lit.)
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-30°C
• SMILES記法: O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
• InChI Key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• 遺伝子情報: human ... ESR1(2099)

詳細

詳細

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Estradiol is a steroid hormone present naturally in the human body. The availability of this hormone is quintessential in older women as it is a determinant of menopausal syndromes. It is utilized for the prevention of cardiovascular diseases.

アプリケーション

Estradiol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生物化学的／生理学的作用

閉経前に卵巣から分泌される主要なエストロゲンです。エストロゲンは、遺伝子転写によるタンパク合成を調節することにより、胚発生期や思春期におけるメス表現型の発達を誘導します。また、ゴナドトロピン産生を促すことにより排卵を誘発します。エストラジオールへの曝露は乳癌の発生率や増殖を増強します。

アナリシスノート

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAC3704 in the slot below. This is an example certificate only and may not be the lot that you receive.

おすすめ製品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全性情報

• ピクトグラム: GHS08,GHS09
• シグナルワード: Danger
• 危険有害性情報: H351,H360FD,H362,H410
• 注意書き: P202 - P260 - P263 - P264 - P273 - P308 + P313
• 危険有害性の分類: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable