E4632

エコナゾール 硝酸塩

• 別名: 1-(2-[(4-クロロフェニル)メトキシ]-2-[2,4-ジクロロフェニル]エチル)-1H-イミダゾール
• 実験式（ヒル表記法）: C₁₈H₁₅Cl₃N₂O · HNO₃
• CAS番号: 24169-02-6
• 分子量: 444.70
• EC Number: 246-053-5
• MDL番号: MFCD00058160
• UNSPSCコード: 51102829
• PubChem Substance ID: 24894567
• NACRES: NA.85

特性

• 形状: powder or crystals
• 品質水準: 200
• 色: white to off-white
• 抗生物質活性スペクトル: Gram-positive bacteria; fungi
• 作用機序: cell membrane | interferes; cell wall synthesis | interferes; enzyme | inhibits
• SMILES記法: O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
• InChI: 1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
• InChI Key: DDXORDQKGIZAME-UHFFFAOYSA-N

詳細

詳細

Chemical structure: imidazole

アプリケーション

Econazole is a broad spectrum antimycotic similar to ketoconazole. It has some action against Gram positive bacteria. It is used topically in dermatomycoses as well as orally and parenterally. It is used for studies on processes such as platelet serotonin uptake, prostanoid biosynthesis, EDHF-mediated relaxation, and Ca²⁺ transport pathways in thymic lymphocytes.

生物化学的／生理学的作用

Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H315,H319
• 注意書き: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves