H7666

IL-12 human

HumanKine^®, recombinant, Xeno-free, >95% (SDS-PAGE), suitable for cell culture

• 동의어(들): Interleukin-12 human, IL-12
• MDL number: MFCD00212975
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 제품명: Interleukin-12 human, HumanKine^®, recombinant, expressed in HEK 293 cells, suitable for cell culture, endotoxin, tested
• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in HEK 293 cells
• 분석: ≥95% (SDS-PAGE)
• 양식: lyophilized
• 효능: ≤2 ng/mL EC₅₀
• 분자량: dimer 57 kDa (glycosylated)
• 포장: pkg of 10 μg
• 기술: cell culture | mammalian: suitable
• 불순물: endotoxin, tested
• 저장 온도: −20°C

설명

애플리케이션

Interleukin-12 (IL-12) human has been used to study IL-12 mediated enhancement of IL-12Rβ2 (IL-12 receptor) expression.

생화학적/생리학적 작용

Interleukin-12 (IL-12) was identified as a factor secreted by human Epstein-Barr (EBV)-transformed B cell lines. IL-12, or Natural Killer Cell Stimulatory Factor (NKSF), is a 75 kDa disulfide-linked heterodimer of a 35 kDa subunit and 40 kDa subunit. IL-12 is produced predominantly by monocytes and NK cells and induces T cells and NK cells to produce IFN-γ. Human IL-12 is not active on mouse cells, but murine IL-12 is active on both murine and human lymphocytes. The biological activity of recombinant human IL-12 was measured by its ability to stimulate the proliferation of PHA-activated human T lymphoblasts. IL-12 has anti-angiogenic properties.

물리적 형태

lyophilized from a 0.2 μm filtered solution of PBS

분석 메모

The specific activity was determined by the dose-dependent release of IFN-γ from the human NK92 cell line in presence of 20 ng/mL rIL-2.

법적 정보

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable