384410

クロロトリメチルシラン 溶液

1.0 M in THF

• 別名: トリメチルクロロシラン
• 化学式: (CH₃)₃SiCl
• CAS番号: 75-77-4
• 分子量: 108.64
• Beilstein: 1209232
• MDL番号: MFCD00000502
• UNSPSCコード: 12352302
• PubChem Substance ID: 24863995
• NACRES: NA.22
• フォーム: liquid

特性

• フォーム: liquid
• 品質水準: 100
• 濃度: 1.0 M in THF
• 密度: 0.88 g/mL at 25 °C
• SMILES記法: C[Si](C)(C)Cl
• InChI: 1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
• InChI Key: IJOOHPMOJXWVHK-UHFFFAOYSA-N

詳細

詳細

Chlorotrimethylsilane (TMSCl) is a silylating agent employed in the silylation of alcohols, amines, carboxylic acids, thiols, and other functional groups. Silyl group serves as a protecting group for these original functional groups.

アプリケーション

Chlorotrimethylsilane (TMSCl) can be used as a reagent:

• To synthesize allenylsilane via carbolithiation of conjugated enynes with aryllithium.
• In the reductive coupling of aldehydes and ketones to produce corresponding 1,2 diols in the presence of zirconocene dichloride and magnesium.
• To prepare 4,4′-bis(trimethylsilyl)bicyclohexyl-2,2′-diene from 1,3-cyclohexadiene by reductive disilylation reaction.

安全性情報

• ピクトグラム: GHS02,GHS08,GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H225,H302,H314,H335,H351
• 注意書き: P201 - P210 - P233 - P261 - P280 - P370 + P378
• 危険有害性の分類: Acute Tox. 4 Oral - Carc. 2 - Flam. Liq. 2 - Skin Corr. 1A - STOT SE 3
• ターゲットの組織: Respiratory system
• 補足的ハザード: EUH014,EUH019
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 1
• 引火点(°F): -4.0 °F - closed cup
• 引火点(℃): -20 °C - closed cup
• 個人用保護具 (PPE): Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter