PHR1432

N-アセチル-D-グルコサミン

Pharmaceutical Secondary Standard; Certified Reference Material

• 別名: 2-アセトアミド-2-デオキシ-D-グルコース, D-GlcNAc
• 実験式（ヒル表記法）: C₈H₁₅NO₆
• CAS番号: 7512-17-6
• 分子量: 221.21
• Beilstein: 1727589
• MDL番号: MFCD00061615
• UNSPSCコード: 41116107
• PubChem Substance ID: 329822596
• NACRES: NA.24

特性

• グレード: certified reference material; pharmaceutical secondary standard
• 品質水準: 300
• 認証: traceable to USP 1010022
• APIファミリー: glucosamine
• CofA: current certificate can be downloaded
• テクニック: HPLC: suitable; gas chromatography (GC): suitable
• mp: 211 °C (dec.) (lit.)
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• 保管温度: 2-30°C
• SMILES記法: CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O
• InChI: 1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8?/m1/s1
• InChI Key: OVRNDRQMDRJTHS-RTRLPJTCSA-N

詳細

詳細

N-Acetylglucosamine (GlcNAc) is a monosaccharide, derived from glucose and undergoes linear polymerization by (1,4)-β-linkages to form the polymer chitin. It is also a component of heterogenous polysaccharides, such as murein and hyaluronic acid. N-acetylglucosamine exhibits anti-inflammatory properties and is considered as a potential drug in the treatment of osteoarthritis. Its antiarthritic mode of mechanism involves the suppression of IL-1β (Interleuken-1β)-induced NO (nitric oxide), cyclooxygenase-2 (COX-2), and IL-6 production by inhibition of expression of iNOS (inducible nitric oxide synthase) protein and mRNA.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

アプリケーション

N-Acetylglucosamine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric, chromatographic, and electrophoretic techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

アナリシスノート

このような2次標準は、入手可能な場合にはUSP、EP、BPの1次標準にマルチトレーサビリティを提供します。

その他情報

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

脚注

To see an example of a Certificate of Analysis for this material enter LRAC3267 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable