H2138

塩化ヘキサメトニウム

solid (hygroscopic)

• 別名: N,N,N,N′,N′,N′-ヘキサメチル-1,6-ヘキサンジアミニウムジクロライド, N,N,N,N′,N′,N′-ヘキサメチルヘキサメチレンジアンモニウムジクロライド, ヘキサメトニウムジクロライド
• 化学式: (CH₃)₃N(Cl)(CH₂)₆N(Cl)(CH₃)₃
• CAS番号: 60-25-3
• 分子量: 273.29
• Beilstein: 3714806
• EC Number: 200-465-1
• MDL番号: MFCD00031563
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277842
• NACRES: NA.77

特性

• 形状: solid (hygroscopic)
• 色: white
• 溶解性: H₂O: soluble; ethanol: soluble
• SMILES記法: [Cl-].[Cl-].C[N+](C)(C)CCCCCC[N+](C)(C)C
• InChI: 1S/C12H30N2.2ClH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
• InChI Key: PYIHTIJNCRKDBV-UHFFFAOYSA-L
• 遺伝子情報: human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143)

詳細

詳細

Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction.

アプリケーション

Hexamethonium chloride has been used to block the responses of nicotinic receptors towards it agonists. It has also been used to study the mechanosensitivity of viscerofugal neurons.

生物化学的／生理学的作用

Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)