710333P

16:0 Cardiolipin

Avanti Research^™ - A Croda Brand

• 別名: 1′,3′-bis[1,2-dipalmitoyl-sn-glycero-3-phospho]-glycerol (sodium salt)
• 実験式（ヒル表記法）: C₇₃H₁₄₀Na₂O₁₇P₂
• CAS番号: 64043-42-1
• 分子量: 1397.81
• MDL番号: MFCD22495327
• UNSPSCコード: 51191904
• NACRES: NA.25

特性

• アッセイ: >99% (TLC)
• フォーム: powder
• 包装: pkg of 1 × 25 mg (710333P-25mg)
• メーカー／製品名: Avanti Research^™ - A Croda Brand
• 脂質タイプ: cardiolipins; phospholipids
• 輸送温度: dry ice
• 保管温度: −20°C

詳細

詳細

Cardiolipin is a unique phospholipid located in the inner mitochondrial membrane, which makes up to 20% of total lipids. It is a non-bilayer anionic phospholipid, which has four acyl chains and small headgroup.

Cardiolipins are anionic teraacylphospholipid, present in inner mitochondrial membrane eukaryotic cells and bacterial cytoplasmic membranes. 16:0 cardiolipin is synthesized by de novo pathway. 16:0 Cardiolipin binds to myeloid differentiation protein 2 (MD2).

The 16:0 number indicates the fatty acyl substituents attached to the carbons of glycerol.

アプリケーション

16:0 Cardiolipin might be suitable to assay mitochondrial fractions for CL-specific phospholipase activity.

生物化学的／生理学的作用

Cardiolipin (CL) plays a key role in coordinating energy metabolism in eukaryotes. Metabolic defect in the CL pathway is implicated in dilated cardiomyopathy. CL is essential for mitochondrial functions and apoptosis. Alternations in CL content and their acyl chain composition, contributes to mitochondrial dysfunction in various pathological conditions.

Cardiolipin maintains the mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy. The association of cardiolipin and cytochrome c determines the action of proteins involved in oxidative phosphorylation and apoptosis.

Cardiolipin regulates the dynamic organization of membranes and cell division. It is involved in proton uptake pathway. Cardiolipin plays an important role in mitochondrial biogenesis, fusion and fission, respiration and protein import. It modulates cell wall biogenesis, vacuole homeostasis, aging, cell cycle and apoptosis.

包装

5 mL Amber Glass Screw Cap Vial (710333P-25mg)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): 755.6 - 820.4 °F
• 引火点(℃): 402 - 438 °C