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製品名
繊維芽細胞増殖因子-酸性 ヒト, FGF-Acidic, recombinant, expressed in E. coli, suitable for cell culture
由来生物
human
品質水準
リコンビナント
expressed in E. coli
アッセイ
≥97% (SDS-PAGE)
フォーム
lyophilized powder
有効性
0.287 ng/mL
品質
endotoxin tested
分子量
15.5 kDa
包装
pkg of 25 μg
保管条件
avoid repeated freeze/thaw cycles
テクニック
cell culture | mammalian: suitable
不純物
≤1.0 EU/mg (LAL test)
UniProtアクセッション番号
保管温度
−20°C
遺伝子情報
human ... FGF1(2246)
詳細
Fibroblast Growth Factor-Acidic (FGF1) belongs to the FGF family and comprises a nuclear export sequence (NES). FGF1 gene is mapped to human chromosome 5q31.3. FGF1 is highly expressed in the central and peripheral nervous system.
アプリケーション
Fibroblast Growth Factor-Acidic human has been used:
- as a component of growth factor cocktail for treating neural stem cell (NSC) transplants
- as a component of Human Neural Stem Cell (HNSC) proliferation medium for Neural Tissue Spheres (NTS) propagation
- as a growth factor component in fibrin matrix to support embryonic day 14 (E14) cells graft survival
生物化学的／生理学的作用
Fibroblast Growth Factor-Acidic (FGF1) is a potent mitogenic agent associated with a variety of tissue origins including liver, vasculature, and skin. These include for a wide variety of mesoderm-derived cells including BALB/c 3T3 fibroblasts, capillary and endocardial endothelial cells, myoblasts, vascular smooth muscle cells, mesothelial cells, glial and astroglial cells, and adrenal cortex. FGF1 participates in glucose homeostasis, adipose tissue remodeling and is a key transducer of the nuclear receptor, peroxisome proliferator-activated receptor γ (PPARγ). FGF1 is a neuronal cell neurotrophic factor and binds to most of the isoforms of the FGF receptor (FGFR) isoforms. Along with FGF2, FGF1 plays a key role in angiogenesis and favors blood vessel formation in chronic inflammatory diseases and cancer. The FGF1 mutant R50E leads to suppression of its angiogenic potential making it a potential anti-angiogenesis agent.
物理的形状
本製品は、凍結乾燥品(20 mM Tris、1 M NaCl、5 mM DTT、サイトカイン1 μgあたりウシ血清アルブミン50 μg含有、0.2 μmフィルター滅菌済み)です。
アナリシスノート
増殖促進活性は、静止期にあるNR6R-3T3線維芽細胞を用いて試験されています。
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
F5542-25UG:
F5542-BULK:
F5542-VAR:
F5542-25UG-PW:
この製品を見ている人はこちらもチェック
Paul Lu et al.
Cell, 150(6), 1264-1273 (2012-09-18)
Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells differentiated into multiple cellular phenotypes, including neurons, which extended large numbers of axons over
Seiji Mori et al.
PloS one, 8(2), e57927-e57927 (2013-03-08)
Fibroblast growth factor-1 (FGF1) and FGF2 play a critical role in angiogenesis, a formation of new blood vessels from existing blood vessels. Integrins are critically involved in FGF signaling through crosstalk. We previously reported that FGF1 directly binds to integrin
Zhifeng Huang et al.
Cell reports, 20(7), 1717-1728 (2017-08-17)
The recent discovery of metabolic roles for fibroblast growth factor 1 (FGF1) in glucose homeostasis has expanded the functions of this classically known mitogen. To dissect the molecular basis for this functional pleiotropy, we engineered an FGF1 partial agonist carrying triple
T Yamashita et al.
Biochemical and biophysical research communications, 277(2), 494-498 (2000-10-18)
We isolated mouse cDNA encoding a novel FGF (251 amino acids). As this is the 23rd documented FGF, we termed it FGF-23. FGF-23 has a hydrophobic amino terminus ( approximately 24 amino acids), which is a typical signal sequence. As
Katarzyna Dominika Sluzalska et al.
Cytokine & growth factor reviews (2020-06-02)
Fibroblast growth factors 1 and 2 (FGF1 and FGF2) are mainly considered as ligands of surface receptors through which they regulate a broad spectrum of biological processes. They are secreted in non-canonical way and, unlike other growth factors, they are
資料
Fibroblast growth factors in cell culture and various growth factors for your research
Role of growth factors in stem cell differentiation and various growth factors for your research at sigmaaldrich.com
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