R7150

Ro 25-6981 塩酸塩 水和物

≥98% (HPLC), powder

• 別名: [R-(R*,S*)]-α-(4-ヒドロキシフェニル)-β-メチル-4-(フェニルメチル)-1-ピペリジンプロパノール 塩酸塩 水和物
• 実験式（ヒル表記法）: C₂₂H₂₉NO₂ · HCl · xH₂O
• CAS番号: 919289-58-0
• 分子量: 375.93 (anhydrous basis)
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278680
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: white
• 溶解性: DMSO: >20 mg/mL
• オーガナイザー: Roche
• SMILES記法: O.Cl.C[C@@H](CN1CCC(CC1)Cc2ccccc2)[C@@H](O)c3ccc(O)cc3
• InChI: 1S/C22H29NO2.ClH.H2O/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;;/h2-10,17,19,22,24-25H,11-16H2,1H3;1H;1H2/t17-,22+;;/m0../s1
• InChI Key: FEINQVNMUYISNW-HVDCVHHPSA-N
• 遺伝子情報: human ... GRIN2B(2904)

詳細

アプリケーション

Ro 25-6981 hydrochloride hydrate has been used:

• as NR2B antagonist for microinjecting rats to study the contribution of NR2B- and NR2A-containing N-methyl-D-aspartate receptors (NMDARs) to the formation of trace and contextual memory in prefrontal cortex (PL)
• as NR2B antagonist to study the effect of the protein expression of hypoxic-ischemic injury NMDAR subunits 2A and 2B in the SVZ of neonatal rats
• to induce deleterious effects upon memory consolidation and long-term potentiation (LTP) generation in the hippocampus

生物化学的／生理学的作用

NR2Bサブユニットを有するNMDAグルタミン酸レセプタ-の強力な選択的アンタゴニストです。

特徴および利点

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves