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[Pharmaconutrition: pharmacological approach to nutrition therapy].

Orvosi hetilap (2014-12-17)
István Télessy
ABSTRACT

Reviewing the literature of nutrition therapy one can conclude that during the last decade the pharmacological action of several nutrients has been demonstrated. However, research activity is still at the beginning and it could be verified in a restricted number of nutrients only that in which conditions (illnesses), dose and duration we can expect therapeutic effect in addition to nutrition. The examples of glutamine, arginine, taurine, leucine, ω-3 fatty acids, however, support the possibility that complex reactions and treatment results observed in certain patients are not purely due to nutritional support but the consequence of additional pharmacological action as well. Evaluation of results of therapeutic intervention is especially difficult because in the everyday practice physicians try to use several therapeutic modalities that can be beneficial for the patient. Therefore, retrospective separation of beneficial components of the therapeutic agents is almost impossible. Only well designed, randomized and multicentric studies can verify specific therapeutic action of certain ingredients ie. nutrients.

MATERIALS
Product Number
Brand
Product Description

Leucine, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
L-Leucine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Sigma-Aldrich
L-Leucine, reagent grade, ≥98% (HPLC)
Sigma-Aldrich
L-Leucine, 99%, FG
Supelco
L-Leucine, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
L-Leucine, BioUltra, ≥99.5% (NT)
Supelco
L-Leucine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Sigma-Aldrich
L-Glutamine solution, 200 mM, Hybri-Max, sterile-filtered, suitable for hybridoma
Sigma-Aldrich
L-Glutamine solution, 200 mM, solution, sterile-filtered, BioXtra, suitable for cell culture
SAFC
L-Glutamine Solution 200 mM, 29.23 mg/mL in saline, solution, suitable for cell culture
Supelco
L-Arginine, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
L-Glutamine, Pharmaceutical Secondary Standard; Certified Reference Material
Arginine, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
L-Glutamine, meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source
Sigma-Aldrich
L-Arginine, reagent grade, ≥98%
Sigma-Aldrich
L-Glutamine, BioUltra, ≥99.5% (NT)
Sigma-Aldrich
L-Arginine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Sigma-Aldrich
L-Glutamine
SAFC
L-Glutamine
Supelco
Taurine, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Taurine, ≥99%
Sigma-Aldrich
Taurine, BioUltra, ≥99.5% (T)
Sigma-Aldrich
Taurine, ≥98%, FG
SAFC
L-Arginine
Sigma-Aldrich
L-Glutamine, γ-irradiated, BioXtra, suitable for cell culture
Sigma-Aldrich
L-Glutamine, ReagentPlus®, ≥99% (HPLC)
Sigma-Aldrich
L-Arginine, BioUltra, ≥99.5% (NT)
Sigma-Aldrich
Taurine, suitable for cell culture, meets USP testing specifications
Sigma-Aldrich
L-Arginine, 99%, FCC, FG
SAFC
Taurine